The Midleton Distillery dates back to 1825, the Murphy brothers converted a wollen mill at the site into a distillery, which grew to be a major operation in the 19th century. In 1966, the three remaining distilleries in the Republic of Ireland, including Cork Distilleries Company merged to form Irish Distillers. All production is at a new, modern facility built next to the old one. The new distillery opened in 1975, and the old one became a visitor center known as the Jameson Experience.

Current products are Jameson, Redbreast, Powers, Midleton Very Rare, Green Spot, Yellow Spot, Blue Spot, and Red Spot as well as Method and Madness (kind of experimental whiskies.